Lehrstuhl für Medizinische Informatik - Publikationen

Zöller D, Haverkamp C, Makoudjou A, Sofack G, Kiefer S, Gebele D, Pfaffenlehner M, Boeker M, Binder H, Karki K, Seidemann C, Schmeck B, Greulich T, Renz H, Schild S, Seuchter SA, Tibyampansha D, Buhl R, Rohde G, Trudzinski FC, Bals R, Janciauskiene S, Stolz D, Fähndrich S. Alpha-1-antitrypsin-deficiency is associated with lower cardiovascular risk: an approach based on federated learning. Respir Res. 2024 Jan 18;25(1):38.
Tabari P, Costagliola G, Rosa MD, Boeker M. State-of-the-Art Fast Healthcare Interoperability Resources (FHIR)–Based Data Model and Structure Implementations: Systematic Scoping Review. JMIR Medical Informatics. 2024 Sep 24;12(1):e58445.
Semler SC, Boeker M, Eils R, Krefting D, Loeffler M, Bussmann J, Wissing F, Prokosch HU. Die Medizininformatik-Initiative im Überblick – Aufbau einer Gesundheitsforschungsdateninfrastruktur in Deutschland. Bundesgesundheitsbl [Internet]. 2024 Jun 5 [cited 2024 Jun 9].
Semler SC, Boeker M, Eils R, Krefting D, Loeffler M, Bussmann J, Wissing F, Prokosch HU. [The Medical Informatics Initiative at a glance-establishing a health research data infrastructure in Germany]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2024 Jun 1;67(6):616–28.
Schüttpelz-Brauns K, Homberg A, Giesler M, Schneider A, Gadewoltz P, Boeker M, Möltner A, Matthes J. Recommendations for reviewing manuscripts of the article types “project report” and “how to” for the GMS Journal for Medical Education. GMS Journal for Medical Education. 2024 Sep 16;41(4):Doc36.
Mocker A, Brendel-Suchanek J, Lieb V, Leb I, Stromer D, Saboor S, Berthele A, Boeker M, Fasching PA, Prokosch HU, Beckmann MW, Hübner H. Implementierung eines Arzt- und Patientenportals für den Use-Case digitales Tumorboard im Rahmen des MIRACUM DIFUTURE Alignment Hubs (MIDIA-Hub). In: Geburtshilfe und Frauenheilkunde [Internet]. Georg Thieme Verlag KG; 2024 [cited 2025 Feb 4]. p. 259.
Martens E, Haase HU, Mastella G, Henkel A, Spinner C, Hahn F, Zou C, Fava Sanches A, Allescher J, Heid D, Strauss E, Maier MM, Lachmann M, Schmidt G, Westphal D, Haufe T, Federle D, Rueckert D, Boeker M, Becker M, Laugwitz KL, Steger A, Müller A. Smart hospital: achieving interoperability and raw data collection from medical devices in clinical routine. Front Digit Health [Internet]. 2024 Mar 6 [cited 2024 Jun 14];6.
Lohr C, Matthies F, Faller J, Modersohn L, Riedel A, Hahn U, Kiser R, Boeker M, Meineke F. De-Identifying GRASCCO – A Pilot Study for the De-Identification of the German Medical Text Project (GeMTeX) Corpus. In: Röhrig R, Grabe N, Hübner UH, Jung K, Sax U, Schmidt CO, Sedlmayr M, Zapf A, editors. Studies in Health Technology and Informatics [Internet]. IOS Press; 2024 [cited 2025 Jan 21].
Lammert J, Tschochohei M, Jansen H, Mathes S, Schatz U, Bronger H, Boeker M, Kiechle M. KI-gestützte klinische Entscheidungsunterstützungssysteme in der (gynäkologischen) Präzisionsonkologie. Gynäkologie. 2024 Dec 1;57(12):793–802.
Lammert J, Pfarr N, Kuligin L, Mathes S, Dreyer T, Modersohn L, Metzger P, Ferber D, Kather JN, Truhn D, Adams LC, Bressem KK, Lange S, Schwamborn K, Boeker M, Kiechle M, Schatz UA, Bronger H, Tschochohei M. Large Language Models-Enabled Digital Twins for Precision Medicine in Rare Gynecological Tumors [Internet]. arXiv; 2024 [cited 2025 Jan 3].
Kunzler AM, Iannizzi C, Burns J, Metzendorf MI, Voigt-Radloff S, Piechotta V, Schmaderer C, Holzmann-Littig C, Balzer F, Benstoem C, Binder H, Boeker M, Dirnagl U, Fichtner F, Golinski M, Grundmann H, Hengel H, Jabs J, Kern WV, Kopp I, Kranke P, Kreuzberger N, Laudi S, Lichtner G, Lieb K, Maun A, Moerer O, Müller A, Mutters NT, Nothacker M, Pfadenhauer LM, Popp M, Rüschemeyer G, Schmucker C, Schwingshackl L, Spies C, Steckelberg A, Stegemann M, Strech D, von Dincklage F, Weibel S, Wunderlich MM, Zöller D, Rehfuess E, Skoetz N, Meerpohl JJ. Informing pandemic management in Germany with trustworthy living evidence syntheses and guideline development: lessons learned from the COVID-19 evidence ecosystem. Journal of Clinical Epidemiology. 2024 Sep 1;173:111456.
Kugic A, Martin I, Modersohn L, Pallaoro P, Kreuzthaler M, Schulz S, Boeker M. Processing of Short-Form Content in Clinical Narratives: Systematic Scoping Review. Journal of Medical Internet Research. 2024 Sep 26;26(1):e57852.
Krefting D, Mutters NT, Pryss R, Sedlmayr M, Boeker M, Dieterich C, Koll C, Mueller M, Slagman A, Waltemath D, Wulf A, Zenker S. Herding Cats in Pandemic Times – Towards Technological and Organizational Convergence of Heterogeneous Solutions for Investigating and Mastering the Pandemic in University Medical Centers. In: Bichel-Findlay J, Otero P, Scott P, Huesing E, editors. Studies in Health Technology and Informatics [Internet]. IOS Press; 2024 [cited 2025 Feb 4].
Knaup-Gregori P, Boeker M, Kirsten T, Krefting D, Schiller E, Schmücker P, Schüttler C, Seim A, Spreckelsen C, Winter A. Kompetenzentwicklung in der Medizininformatik-Initiative (MII) – Lehrangebote für einen souveränen und sicheren Umgang mit medizinischen Daten. Bundesgesundheitsbl [Internet]. 2024 May 15 [cited 2024 May 16].
Knaup-Gregori P, Boeker M, Kirsten T, Krefting D, Schiller E, Schmücker P, Schüttler C, Seim A, Spreckelsen C, Winter A. [Development of competencies in the Medical Informatics Initiative (MII)-educational offers for a competent and secure handling of medical data]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2024 Jun 1;67(6):693–700.
Boeker M, Zöller D, Blasini R, Macho P, Helfer S, Behrens M, Prokosch HU, Gulden C. Effectiveness of IT-supported patient recruitment: study protocol for an interrupted time series study at ten German university hospitals. Trials. 2024 Feb 16;25(1):125.
Beliën J, Beusink M, Boeker M, Boiten JW, Bolding N, Buckow K, Crameri K, Drepper J, Kleinert P, Ganslandt T, Geiger TR, Prokosch HU, Sax U, Scherag A, Schug SH, Semler SC, Steiner M, Wissing F, Zenker S. Transnational health care research – carefully connecting the dots towards a European Health Data Space [Internet]. Zenodo; 2024 Jul [cited 2024 Jul 3].
Bayas A, Mansmann U, Ön BI, Hoffmann VS, Berthele A, Mühlau M, Kowarik MC, Krumbholz M, Senel M, Steuerwald V, Naumann M, Hartberger J, Kerschensteiner M, Oswald E, Ruschil C, Ziemann U, Tumani H, Vardakas I, Albashiti F, Kramer F, Soto-Rey I, Spengler H, Mayer G, Kestler HA, Kohlbacher O, Hagedorn M, Boeker M, Kuhn K, Buchka S, Kohlmayer F, Kirschke JS, Behrens L, Zimmermann H, Bender B, Sollmann N, Havla J, Hemmer B, Berlis A, Wiestler B, Kümpfel T, Seelos K, Dünschede J, Kemmner R, Beer M, Dietrich J, Schaller J, the ProVal-MS study group. Prospective study validating a multidimensional treatment decision score predicting the 24-month outcome in untreated patients with clinically isolated syndrome and early relapsing–remitting multiple sclerosis, the ProVal-MS study. Neurol Res Pract. 2024 Mar 7;6(1):15.
Ammon D, Kurscheidt M, Buckow K, Kirsten T, Löbe M, Meineke F, Prasser F, Saß J, Sax U, Stäubert S, Thun S, Wettstein R, Wiedekopf JP, Wodke JAH, Boeker M, Ganslandt T. [Interoperability Working Group: core dataset and information systems for data integration and data exchange in the Medical Informatics Initiative]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2024 Jun 1;67(6):656–67.
Ammon D, Kurscheidt M, Buckow K, Kirsten T, Löbe M, Meineke F, Prasser F, Saß J, Sax U, Stäubert S, Thun S, Wettstein R, Wiedekopf JP, Wodke JAH, Boeker M, Ganslandt T. Arbeitsgruppe Interoperabilität: Kerndatensatz und Informationssysteme für Integration und Austausch von Daten in der Medizininformatik-Initiative. Bundesgesundheitsbl [Internet]. 2024 May 16 [cited 2024 May 16]
Weis J, Wolf LR, Boerries M, Kassahn D, Boeker M, Dresch C. Identification of the Needs and Preferences of Patients With Cancer for the Development of a Clinic App: Qualitative Study. JMIR Cancer. 2023 Jul 27.
Scheible R, Thomczyk F, Blum M, Rautenberg M, Prunotto A, Yazijy S, et al. Integrating row level security in i2b2: segregation of medical records into data marts without data replication and synchronization. JAMIA Open. 2023 Oct 1;6(3).
Scheible R, Alkier D, Wendroth J, Mayer J, Boeker M. FHIR DataProvider for ReactAdmin: Leveraging User Interface Creation for Medical Web Applications. Stud Health Technol Inform. 2023 Jun 1;305:110–4.
Schönecker S, Hoffmann V, Albashiti F, Thasler R, Hagedorn M, Louiset ML, Kopczak A, Rösler J, Baki E, Wunderlich S, Kohlmayer F, Kuhn K, Boeker M, Tünnerhoff J, Poli S, Ziemann U, Kohlbacher O, Althaus K, Müller S, Ludolph A, Kestler HA, Mansmann U, Dieterich M, Kellert L. PREDICT-juvenile-stroke: PRospective evaluation of a prediction score determining individual clinical outcome three months after ischemic stroke in young adults - a study protocol. BMC Neurol 2023; 23(1)
Metzger P, Hess ME, Blaumeiser A, Pauli T, Schipperges V, Mertes R, Christoph J, Unberath P, Reimer N, Scheible R, Illert AL, Busch H, Andrieux G, Boerries M . MIRACUM-Pipe: An Adaptable Pipeline for Next-Generation Sequencing Analysis, Reporting, and Visualization for Clinical Decision Making. Cancers (Basel) 2023; 15(13)
Stellmach C, Sass J, Auber B, Boeker M, Wienker T, Heidel AJ, Benary M, Schumacher S, Ossowski S, Klauschen F, Möller Y, Schmutzler R, Ustjanzew A, Werner P, Tomczak A, Hölter T, Thun S. Creation of a structured molecular genomics report for Germany as a local adaption of HL7's Genomic Reporting Implementation Guide. J Am Med Inform Assoc 2023; 30(6): 1179-1189
Lichtner G, Alper BS, Jurth C, Spies C, Boeker M, Meerpohl JJ, von Dincklage F. Representation of evidence-based clinical practice guideline recommendations on FHIR. J Biomed Inform 2023; 139()
Lichtner G, Spies C, Jurth C, Bienert T, Mueller A, Kumpf O, Piechotta V, Skoetz N, Nothacker M, Boeker M, Meerpohl JJ, von Dincklage F. Automated Monitoring of Adherence to Evidenced-Based Clinical Guideline Recommendations: Design and Implementation Study. J Med Internet Res 2023; 25
Noll R, Frischen LS, Boeker M, Storf H, Schaaf J . Machine translation of standardised medical terminology using natural language processing: A scoping review. N Biotechnol 2023; 77: 120-129
Rinaldi E, Drenkhahn C, Gebel B, Saleh K, Tönnies H, von Loewenich FD, Thoma N, Baier C, Boeker M, Hinske LC, Diaz LAP, Behnke M, Ingenerf J, Thun S . Towards interoperability in infection control: a standard data model for microbiology. Sci Data 2023; 10(1)
Meineke F, Modersohn L, Loeffler M, Boeker M. Announcement of the German Medical Text Corpus Project (GeMTeX). Stud Health Technol Inform 2023; 302(): 835-836
Draeger C, Tute E, Schmidt CO, Waltemath D, Boeker M, Winter A, Löbe M. Identifying Relevant FHIR Elements for Data Quality Assessment in the German Core Data Set. Stud Health Technol Inform 2023; 302: 272-276
Hapfelmeier A, On BI, Mühlau M, Kirschke JS, Berthele A, Gasperi C, Mansmann U, Wuschek A, Bussas M, Boeker M, Bayas A, Senel M, Havla J, Kowarik MC, Kuhn K, Gatz I, Spengler H, Wiestler B, Grundl L, Sepp D, Hemmer B. Retrospective cohort study to devise a treatment decision score predicting adverse 24-month radiological activity in early multiple sclerosis. Therap Adv Neurol Dis 2023; 16()
M Schoenthaler, UA Fichtner, M Boeker, D Zoeller, H Binder, H-U Prokosch, F Praus, T Walther, M Glienke, P Horki, C Gratzke, E Farin-Glattacker.A nationwide registry for recurrent urolithiasis in the upper urinary tract–The RECUR study protocol. BMC Health Services Research 22 (1), 1-8. 2022
J Scheer, A Volkert, N Brich, L Weinert, N Santhanam, M Krone, T Ganslandt, M Boeker, T Nagel. Visualization Techniques of Time-Oriented Data for the Comparison of Single Patients With Multiple Patients or Cohorts: Scoping Review. Journal of Medical Internet Research 24 (10), e38041. 2022
A Vass, I Reinecke, M Boeker, H-U Prokosch, C Gulden. Availability of Structured Data Elements in Electronic Health Records for Supporting Patient Recruitment in Clinical Trials. Studies in Health Technology and Informatics 290, 130-134. 2022
S Schulz, M Boeker, A Prunotto. Validation of Multiple Path Translation for SNOMED CT Localisation. Studies in health technology and informatics 294, 961-962. 2022
B Saravi, F Hassel, S Ülkümen, A Zink, V Shavlokhova, S Couillard-Despres, M Boeker, P Obid, G Michael Lang. Artificial intelligence-driven prediction modeling and decision making in spine surgery using hybrid machine learning models. Journal of Personalized Medicine 12 (4), 509. 2022
G Lichtner, C Spies, C Jurth, T Bienert, A Mueller, O Kumpf, V Piechotta, N Skoetz, M Nothacker, M Boeker, JJ Meerpohl, F von Dincklage. Design and implementation of a system for automated monitoring of adherence to evidenced-based clinical guideline recommendations. medRxiv. 2022
P Strecker, M Boeker, S Buechner, R Scheible. Usability Evaluation of a Modern Multilingual MeSH Browser Advances in Informatics, Management and Technology in Healthcare, 37-40, 2022
R Scheible, D Caliskan, P Fischer, F Thomczyk, S Zabka, H Schneider, M Boeker, S Schulz, H-U Prokosch, C Gulden. AHD2FHIR: A Tool for Mapping of Natural Language Annotations to Fast Healthcare Interoperability Resources–A Technical Case Report. MEDINFO 2021: One World, One Health–Global Partnership for Digital Innovation 32-36. 2022
I Leb, S Magnin, M Boeker, H-U Prokosch, E Ammenwerth, M Glöggler. Classification of Patient Portals Described in Evaluation Studies Using the TOPCOP Taxonomy. Healthcare of the Future 2022, 28-33. 2022
G Lichtner, C Jurth, BS Alper, C Spies, M Boeker, JJ Meerpohl, F von Dincklage. Representation of evidence-based clinical practice guideline recommendations on FHIR. medRxiv. 2022
D Fugmann, M Boeker, S Holsteg, N Steiner, J Prins, A Karger. A Systematic Review: The Effect of Cancer on the Divorce Rate. Frontiers in psychology 13. 2022
R Scheible, P Strecker, S Yazijy, F Thomczyk, R Talpa, A Puhl, M Boeker. A Multilingual Browser Platform for Medical Subject Headings. Informatics and Technology in Clinical Care and Public Health 289, 384-387, 2022
T Meurers, R Bild, KM Do, F Prasser. A scalable software solution for anonymizing high-dimensional biomedical data. GigaScience 10 (10), 2021
R Bild, M Bialke, K Buckow, T Ganslandt, K Ihrig, R Jahns, A Merzweiler, S Roschka, B Schreiweis, S Stäubert, S Zenker, F Prasser. Towards a comprehensive and interoperable representation of consent-based data usage permissions in the German medical informatics initiative. BMC Medical Informatics and Decision Making, 2020
J Eicher, R Bild, H Spengler, KA Kuhn, F Prasser. A comprehensive tool for creating and evaluating privacy-preserving biomedical prediction models. BMC medical informatics and decision making 20 (1), 1-14, 2020
H Spengler, I Gatz, F Kohlmayer, KA Kuhn, F Prasser. Improving Data Quality in Medical Research: A Monitoring Architecture for Clinical and Translational Data Warehouses. 2020 IEEE 33rd International Symposium on Computer-Based Medical Systems (CBMS), 415-420, 2020
H Spengler, C Lang, T Mahapatra, I Gatz, KA Kuhn, F Prasser. Enabling Agile Clinical and Translational Data Warehousing: Platform Development and Evaluation. JMIR Medical Informatics 8 (7), e15918, 2020
F Prasser, J Eicher, H Spengler, R Bild, KA Kuhn. Flexible data anonymization using ARX—Current status and challenges ahead. Software: Practice and Experience 50 (7), 1277-1304, 2020
LB Pape-Haugaard. Efficient Protection of Health Data from Sensitive Attribute Disclosure. Digital Personalized Health and Medicine: Proceedings of MIE 2020 270, 193, 2020
R Bild, KA Kuhn, F Prasser. Better Safe than Sorry–Implementing Reliable Health Data Anonymization. Digital Personalized Health and Medicine, 68-72, 2020
H Spengler, F Prasser. Protecting Biomedical Data Against Attribute Disclosure.. GMDS, 207-214, 2019
F Prasser, H Spengler, R Bild, J Eicher, KA Kuhn. Privacy-enhancing ETL-processes for biomedical data. International journal of medical informatics 126, 72-81, 2019
R Bild, KA Kuhn, F Prasser. SafePub: A Truthful Data Anonymization Algorithm With Strong Privacy Guarantees. Proc. Priv. Enhancing Technol. 2018 (1), 67-87, 2018
J Eicher, KA Kuhn, F Prasser. An experimental comparison of quality models for health data de-identification. MEDINFO 2017: Precision Healthcare through Informatics, 704-708, 2017
M Brandizi, O Melnichuk, R Bild, F Kohlmayer, B Rodriguez-Castro, H Spengler, KA Kuhn, W Kuchinke, C Ohmann, T Mustonen, M Linden, T Nyrönen, I Lappalainen, A Brazma, U Sarkans. Orchestrating differential data access for translational research: a pilot implementation. BMC Medical Informatics and Decision Making 17 (1), 1-14, 2017
F Prasser, J Eicher, R Bild, H Spengler, KA Kuhn. A tool for optimizing de-identified health data for use in statistical classification. 2017 IEEE 30th International Symposium on Computer-Based Medical Systems (CBMS), 169-174, 2017
F Prasser, F Kohlmayer, H Spengler, KA Kuhn. A scalable and pragmatic method for the safe sharing of high-quality health data. IEEE journal of biomedical and health informatics 22 (2), 611-622, 2017
R Merino-Martinez, L Norlin, D van Enckevort, G Anton, S Schuffenhauer, K Silander, L Mook, P Holub, R Bild, M Swertz, J-E Litton. Toward global biobank integration by implementation of the minimum information about biobank data sharing (MIABIS 2.0 Core). Biopreservation and biobanking 14 (4), 298-306, 2016
KA Kuhn, R Bild, G Anton, S Schuffenhauer, H Wichmann. Vernetzung von Biobanken großer europäischer Kohorten (EU-Projekt BBMRI-LPC). Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz 59 (3), 385-389, 2016
KA Kuhn, R Bild, G Anton, S Schuffenhauer, HE Wichmann. Connecting biobanks of large european cohorts (EU project BBMRI-LPC). Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 59 (3), 385-389, 2016
F Prasser, R Bild, J Eicher, H Spengler, F Kohlmayer, KA Kuhn. Lightning: Utility-Driven Anonymization of High-Dimensional Data. Trans. Data Priv. 9 (2), 161-185, 2016
F Prasser, R Bild, KA Kuhn. A Generic Method for Assessing the Quality of De-Identified Health Data. MIE, 312-316, 2016
K Kuhn, R Bild, H Spengler. BBMRI catalogue. Journal of Clinical Bioinformatics 5 (1), 1-2, 2015